folic acid benefits
Maternal folate status is a predictor of neural tube defect risk, which has led to national public health policies regarding folic acid supplementation for women who are or may become pregnant. The health benefits of vitamin B9, also known as folic acid, include prevention of heart disorders, stroke, cancer, and birth defects during pregnancy. Healthline Media does not provide medical advice, diagnosis, or treatment. Folic acid helps reduce the risk of getting neural tube defects... 2. For example, on average, adult men consume 602 mcg DFE per day, and adult women consume 455 mcg DFE per day, exceeding the 400 mcg DFE intake requirement through food alone (7). Folic acid is a man-made form of a B vitamin called folate. Folate is responsible for healthy cell growth. Ask your doctor about taking folic acid if you are breast-feeding. Folic acid helps your body produce and maintain new cells, and also helps prevent changes to DNA that may lead to cancer. Your body can’t make folate, so it must be obtained through dietary intake. In fact, 19% of adolescent girls ages 14–18 don’t meet the estimated average requirement (EAR) for folate. Do not take extra medicine to make up the missed dose. Learn about…. Call your doctor for medical advice about side effects. A recent study in 200 mothers found that mothers with higher blood concentrations of folate at the 14th week of gestation were more likely to have children with autism spectrum disorder (ASD) (42). seizure medication such as phenytoin (Dilantin) or primidone (Mysoline). Folic acid is sometimes used in combination with other medications to treat pernicious, aplastic, or normocytic anemia. You can take a multivitamin or a small, single supplement of folic acid. Talk to your doctor about taking folic acid during pregnancy. Folate is essential to good health. 5-methyltetrahydrofolate has similar bioavailability. … Additionally, folate supplements may be helpful for those with alcohol use disorders. It should be noted that supplementing with 5-methyltetrahydrofolate rather than folic acid may reduce potential interactions with certain medications, including methotrexate (3). We comply with the HONcode standard for trustworthy health information -, Folic acid pregnancy and breastfeeding warnings, Vitamin/Mineral Supplementation and Deficiency. When taken in supplement form, 5-methyltetrahydrofolate has the same — if not slightly higher — bioavailability than folic acid supplements (3). Many clinical studies show that when women take folic acid before conception, t… Folic acid is nearly 100% bioavailable when taken on an empty stomach and 85% bioavailable when taken with food. If you’re pregnant or trying to conceive, you’ll need folic acid supplements. Do not take it in larger amounts or for longer than recommended. Folic acid has gained recognition for its benefits … Even normal but low folate levels are associated with an increased risk of mental impairment in older adults (11, 12). This suggests that supplementing with folic acid around week 14 of pregnancy was more common in women whose children later developed ASD (42). Usual Pediatric Dose for Folic Acid Deficiency: Infant: Research has shown that supplementing with folic acid may reduce homocysteine levels and heart disease risk. Given folate’s importance for maternal and fetal health and the difficulty many women have meeting their needs through diet alone, it’s recommended that all women who are planning to become pregnant or capable of becoming pregnant supplement daily with 400–800 mcg of folic acid starting at least 1 month before becoming pregnant and continuing through the first 2–3 months of pregnancy (7). 1 to 10 years: 0.1 to 0.4 mg orally, intramuscularly, subcutaneously or IV once a day. Genetic polymorphisms that affect folate status, methylenetetrahydrofolate reductase (MTHFR). H… Because of this variability in absorption, DFEs were developed according to the following equation (4): Adults need about 400 mcg DFE of folate per day to replenish daily folate losses. It’s important to consult your child’s healthcare provider before giving your child a folic acid supplement to determine appropriateness and safety. Do not start a new medication without telling your doctor. Folic acid is also sold in concentrated form in dietary supplements. A large study showed that women who consumed more … However, folinic acid, folic acid, and 5-methyltetrahydrofolate are the most widely used in dietary supplements. Take folic acid with a full glass of water. Because a high intake of folic acid can result in high levels of unmetabolized folic acid in the blood and may be associated with negative health outcomes, many experts suggest that pregnant women take 5-methyltetrahydrofolate, the biologically active form of folate, rather than folic acid (40). Since the 1990s, flour and other food staples have been fortified with folic acid based on study results linking low folate status in women with a significantly increased risk of neural tube defects in their children. Aside from the folic acid benefits attained by consuming folate through either food sources or a multi-vitamin, topically applied folate may aid in reducing the signs of premature aging, according to some … Reduce The Risk Of Neural Tube Defects In The Fetus. Tell your doctor about all other medications you use, especially: tetracycline (Ala-Tet, Brodspec, Sumycin); a barbiturate such as butabarbital (Butisol), secobarbital (Seconal), pentobarbital (Nembutal), or phenobarbital (Solfoton); or. Studies have demonstrated that folic acid supplements may improve brain function in those with mental impairment and help treat Alzheimer’s disease. Folinic acid is superior to folic acid, as it’s more effective at raising blood folate levels (51). In this case, folic acid will help to metabolize homocysteine into methionine, which is … Research on use of folate and oral folic acid supplements for specific conditions shows: 1. People with severe MTHFR deficiency can’t make 5-methyltetrahydrofolate, the biologically active form of folate, and may have extremely low folate levels (30). Folic acid and folate are two forms of vitamin B9. Folic Acid vs. Folate — What’s the Difference? One of the best benefits of folic acid for men is heart disease prevention. High … > 10 years: 0.5 orally, intramuscularly, subcutaneously or IV once a day. Genetic polymorphisms in folate metabolizing enzymes, such as methylenetetrahydrofolate reductase (MTHFR), can affect health by interfering with folate levels in the body. It helps make DNA and produce red blood cells. Plus, studies have shown that 5-methyltetrahydrofolate is more effective at increasing red blood cell folate concentrations. Version: 5.01. ferrous sulfate, ergocalciferol, Zinc, thiamine, leucovorin, l-methylfolate, Deplin, Folacin-800. Your body uses folate for a wide array of critical functions, including (1, 2, 3, 4): Folate is involved in a number of vital metabolic processes, and deficiency leads to an array of negative health outcomes, including megaloblastic anemia, increased risk of heart disease and certain cancers, and birth defects in infants whose mothers were deficient in folate (1). Get emergency medical help if you have any of these signs of an allergic reaction to folic acid: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Though some studies have associated high maternal levels of folic acid with a decreased risk of autism and improved mental outcomes in children, others have associated high levels of unmetabolized folic acid in the blood with an increased risk of autism and negative effects on neurocognitive development. May continue until clinical symptoms of folate deficiency and the hematological profile have normalized. Folic acid is used to: treat or prevent folate … Overdose symptoms may include numbness or tingling, mouth or tongue pain, weakness, tired feeling confusion, or trouble concentrating. Synthetic folic acid is thought to have 100% absorbability when consumed on an empty stomach, while folic acid found in fortified foods is thought to have only 85% absorbability. Folate stores in the body range between 10–30 mg, most of which is stored in your liver, while the remaining amount is stored in blood and tissues. Folic acid is used to treat folic acid deficiency and certain types of anemia. What’s more, folic acid supplements may help reduce high blood pressure, a known heart disease risk factor (20). Firstly it helps to prevent the formation of lines and wrinkles by making new skin cells. A 2019 study in 180 adults with mild cognitive impairment (MCI) demonstrated that supplementing with 400 mcg of folic acid per day for 2 years significantly improved measures of brain function, including verbal IQ and reduced blood levels of certain proteins involved in the development and progression of Alzheimer’s disease, compared with a control group (13).